The highest expressed forms in liver are CYPs 3A4, 2C9, 2C8, 2E1, uses of enzymes in daily activities 1A2, while 2A6, 2D6, 2B6, 2C19 and 3A5 are less abundant and CYPs 2J2, 1A1, and 1B1 are mainly expressed extrahepatically. Expression of each CYP is influenced by a unique combination of mechanisms and factors including genetic polymorphisms, induction by xenobiotics, regulation by cytokines, hormones and during disease states, as well as sex, age, and others. Multiallelic genetic polymorphisms, which strongly depend on ethnicity, play a major role for the function of CYPs 2D6, 2C19, 2C9, 2B6, 3A5 and 2A6, and lead to distinct pharmacogenetic phenotypes termed as poor, intermediate, extensive, and ultrarapid metabolizers. Here we review the recent progress on drug metabolism activity profiles, interindividual variability and regulation of expression, and the functional and clinical impact of genetic variation in drug metabolizing P450s. Pearson Prentice Hall and our other respected imprints provide educational materials, technologies, assessments and related services across the secondary curriculum.
Take a closer look at the instructional resources we offer for secondary school classrooms. Use the Web Code found in your Pearson textbook to access supplementary online resources. Gain access to thousands of additional definitions and advanced search features—ad free! RNA as part of its defense system. Will High-Tech Skin Put an End to Needle Sticks for Diabetes? These example sentences are selected automatically from various online news sources to reflect current usage of the word ‘enzyme. Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Subscribe to America’s largest dictionary and get thousands more definitions and advanced search—ad free!
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