20 and 46 amino acids, respectively. Human renin is secreted by at least the enzyme renin is produced by the kidney cellular pathways: a constitutive pathway for the secretion of the precursor prorenin and a regulated pathway for the secretion of mature renin. Angiotensin II is a potent constrictor of all blood vessels. It acts on the smooth muscle and, therefore, raises the resistance posed by these arteries to the heart. The heart, trying to overcome this increase in its ‘load’, works more vigorously, causing the blood pressure to rise.
L in the upright position. Renin’s primary function is therefore to eventually cause an increase in blood pressure, leading to restoration of perfusion pressure in the kidneys. Renin is secreted from juxtaglomerular kidney cells, which sense changes in renal perfusion pressure, via stretch receptors in the vascular walls. Together, the macula densa and juxtaglomerular cells comprise the juxtaglomerular complex. I over that shown by soluble renin. 12 kb of DNA and contains 8 introns. Many—but not all—patients and families with this disease suffer from an elevation in serum potassium and unexplained anemia relatively early in life.