Histone modifications and DNA methylation are epigenetic marks that effect gene expression patterns. The highest expressed forms in liver are CYPs 3A4, 2C9, 2C8, 2E1, and 1A2, while 2A6, 2D6, 2B6, 2C19 and 3A5 are less abundant and CYPs 2J2, 1A1, and 1B1 are mainly expressed extrahepatically. Expression of each CYP is influenced by a unique combination of mechanisms and factors including genetic polymorphisms, induction by xenobiotics, regulation by cytokines, hormones and during disease states, as well as sex, age, and others. Multiallelic genetic polymorphisms, which strongly depend on ethnicity, play a major role for the function of CYPs 2D6, 2C19, 2C9, 2B6, 3A5 and 2A6, and lead to distinct pharmacogenetic phenotypes termed as poor, intermediate, extensive, and ultrarapid metabolizers. Here we review the recent progress on drug metabolism activity profiles, interindividual variability and regulation of expression, and the functional what type of enzyme is phosphofructokinase clinical impact of genetic variation in drug metabolizing P450s.
All our epigenetics resources industrial enzymes and their applications market one place, quicker and easier for you to find our latest webinars, protocols, hints and tips. See how we can help you with your epigenetics research. Take a look at our latest webinars, protocols and guides covering the essential mechanisms of DNA methylation, histone modification and non-coding RNAs. Articles and webinars on the newest DNA methylation techniques, and products for your experiments. Find resources and technologies to help you with your miRNA and non-coding RNA research. Protocols and webinars to cover the basics, ChIP-grade antibodies and kits to advance your research. Looking for current epigenetics research?
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